Floor-plate-derived netrin-1 is dispensable for commissural axon guidance
نویسندگان
چکیده
منابع مشابه
Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System
During nervous system development, spinal commissural axons project toward floor plate cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein made by floor plate cells, can attract spinal commissural axons and repel trochlear axons in vitro, but its role in vivo is unknown. Netrin-1 deficient mice exhibit defects in spinal commissural axon projections that ...
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Guofa Liu,1 Weiquan Li,3 Xue Gao,1,2 Xiaoling Li,1 Claudia Jürgensen,1 Hwan-Tae Park,4 Nah-Young Shin,5 Jian Yu,1 Ming-Liang He,6 Steven K. Hanks,5 Jane Y. Wu,1,2 Kun-Liang Guan,3 and Yi Rao1 1Department of Neurology, 2Robert H. Lurie Comprehensive Cancer Center, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, 3Life Sciences Institute, ...
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There is increasing evidence that heparan sulfate (HS) plays an essential role in various axon guidance processes. These observations, however, have not addressed whether HS is required cell autonomously as an axonal coreceptor or as an environmental factor that modulates the localization of guidance molecules in the terrain in which growing axons navigate. Here we demonstrate that netrin-1-med...
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The multifunctional protein netrin-1 was initially discovered as the main attractive cue for commissural axon guidance by acting through its receptor DCC. Recently, we have shown that netrin-1 also interacts with the orphan transmembrane receptor amyloid precursor protein (APP). APP is cleaved by proteases, generating amyloid-β peptide, the main component of the amyloid plaques that are associa...
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Morphogens have been identified as guidance cues for postcrossing commissural axons in the spinal cord. Shh has a dual effect on postcrossing commissural axons: a direct repellent effect mediated by Hhip as a receptor, and an indirect effect by shaping a Wnt activity gradient. Wnts were shown to be attractants for postcrossing commissural axons in both chicken and mouse embryos. In mouse, the e...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature22331